Thursday, May 16, 2013

1st day of 2-day Andy Williams auction brings $46M

NEW YORK (AP) ? Singer Andy Williams' eclectic art collection has brought $46 million at a New York City auction.

The works sold on Wednesday, the first of a two-day sale at Christie's.

The late singer's taste ranged from contemporary, impressionist and modern to Latin American and 20th century decorative art and design.

He collected over a 60-year period. The works were displayed at his California and Missouri homes, as well as his Moon River Theater in Branson, Mo.

Auction highlights included Willem de Koonings' "Untitled XVII," which fetched $9.7 million and Jean-Michel Basquiat's (zhahn mee-SHEHL' BAH'-skee-ahts) "Furious Man, which realized $5.7 million.

Williams died last year at age 84.

The baritone was known for his wholesome, middle-America appeal and easy-listening hits including the theme to the Oscar-winning tearjerker "Love Story."

___

Online: www.christies.com

Source: http://news.yahoo.com/1st-day-2-day-andy-williams-auction-brings-051931449.html

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NVIDIA Shield available in June for $349, preorders begin today

NVIDIA Shield specs release date

NVIDIA on Tuesday announced the upcoming availability of its Shield gaming console. The Android-powered handheld will be one of the first devices to be equipped with NVIDIA?s?Tegra 4 processor, which includes 72 custom graphics cores and four Cortex-A15 processing cores. The controller features dual analog joysticks, a full-sized D-Pad, left and right analog triggers and A/B/X/Y buttons, and can even stream PC games from a?GeForce?GTX?GPU-powered computer. The Shield is also equipped with?a built-in 5-inch 720p multi-touch display, 2GB of RAM, 16GB of internal storage, a 3.5mm headphone jack, a microSD slot, GPS, Bluetooth 3.0, a mini-HDMI port and runs a stock version of Android 4.2.2 Jelly Bean.

[More from BGR: The best sign yet for Windows 8.1: Microsoft is making it a free upgrade]

?These pieces, put together by a company full of gaming fanatics, add up to an amazing new open platform gaming portable,? NVIDIA said. ?It?s the best way to play Android games. And because it?s an Android device, it works with both Tegra-optimized and regular Android games ? as well as Android apps.?

[More from BGR: The Boy Genius Report: What is BlackBerry thinking?]

Users will be able to access apps and games through the traditional Google Play store and also NVIDIA?s TegraZone marketplace.

Shield will begin shipping in June for $349 and will be available from Newegg, Gamestop, Micro Center and Canada Computers. NVIDIA will begin taking preorders on Tuesday for those users who previously registered, and will open orders up to the general public on May 20th.

This article was originally published on BGR.com

Source: http://news.yahoo.com/nvidia-shield-available-june-349-preorders-begin-today-224035952.html

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From ocean to land: The fishy origins of our hips

Tuesday, May 14, 2013

New research has revealed that the evolution of the complex, weight-bearing hips of walking animals from the basic hips of fish was a much simpler process than previously thought.

Tetrapods, or four-legged animals, first stepped onto land about 395 million years ago. This significant change was made possible by strong hipbones and a connection through the spine via an ilium - features that were not present in the fish ancestors of tetrapods.

In a study published in the journal Evolution and Development, Dr Catherine Boisvert of the Australian Regenerative Medicine Institute at Monash University, MacQuarie University's Professor Jean Joss and Professor Per Ahlberg of Uppsala University examined the hip structures of some of human's closest fish cousins.

They found the differences between us and them are not as great as they appear - most of the key elements necessary for the transformation to human hips were actually already present in our fish ancestors.

Dr Boisvert and her collaborators compared the hip development - bones and musculature - of the Australian lung fish and the Axolotl, commonly known as the Mexican Walking Fish.

The results showed that, surprisingly, the transition from simple fish hip to complex weight-bearing hip could be done in a few evolutionary steps.

"Many of the muscles thought to be "new" in tetrapods evolved from muscles already present in lungfish. We also found evidence of a new, more simple path by which skeletal structures would have evolved," Dr Boisvert said.

The researchers found that the sitting bones would have evolved by the extension of the already existing pubis. The connection to the vertebral column could have evolved from an illiac process already present in fish.

"The transition from ocean-dwelling to land-dwelling animals was a major event in the evolution of terrestrial animals, including humans, and an altered hip was an essential enabling step," Dr Boisvert said.

"Our research shows that what initially appeared to be a large change in morphology could be done with relatively few developmental steps."

###

Monash University: http://www.monash.edu.au

Thanks to Monash University for this article.

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Source: http://www.labspaces.net/128250/From_ocean_to_land__The_fishy_origins_of_our_hips

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IRS "failed to be completely truthful" to House committee, lawmakers say (Washington Bureau)

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Wednesday, May 15, 2013

Nokia teases unannounced Lumia phone with upgraded camera, metal body [video]

CENTENNIAL, Colo. (AP) ? Changing his plea to not guilty by reason of insanity is seen as James Holmes' best hope of avoiding the death penalty. His lawyers have avoided taking the step, though, because it also carries risks for Holmes, charged with killing 12 people and injuring 70 on July 20 at a packed midnight showing of "The Dark Knight Rises" in Aurora.

Source: http://news.yahoo.com/nokia-teases-unannounced-lumia-phone-upgraded-camera-metal-124547557.html

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Israel PM Netanyahu to visit Russia's Putin on Tuesday for Syria talks

By Alasdair Fotheringham FIRENZE, Italy, May 12 (Reuters) - Pre-race favourite Bradley Wiggins endured another difficult day on a rain-lashed ninth stage of the Giro d'Italia although defending champion Ryder Hesjedal suffered most, dropping to 11th overall. Britain's Wiggins, who crashed on a descent on Friday, remained fourth overall, one minute and 16 seconds behind leader Vincenzo Nibali despite for a time losing contact with the Italian and the other contenders on a technical downhill section about 55 km from Sunday's stage finish in Firenze. ...

Source: http://news.yahoo.com/israel-pm-netanyahu-visit-russias-putin-tuesday-syria-053811520.html

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Amy Hillman: The Rise in Business-Analytics Degrees

You don't have to be a computer-science major to feel surrounded by terms like big data, cloud computing and algorithms. "The cloud" is a common topic of conversation, and without even trying, you regularly participate in the giving and receiving of big data. For example, each time you visit Facebook, download a game on your iPhone, or send a request to a LinkedIn contact, you are participating in the big data machine.

So, who are the people who analyze all of this data? They are business analysts, one of the fastest-growing jobs of 2013. You can find them at a variety of organizations, including Fortune 100 companies, small businesses, universities, nonprofits and government organizations.

The role of a business analyst is to aggregate data to figure out how his or her organization can leverage the data to operate more efficiently and effectively. The Harvard Business Review calls the position of business analyst or data scientist the "sexiest job of the 21st century." Business-analyst jobs are predicted to increase by 22 percent by 2020, according to the U.S. Bureau of Labor Statistics.

Unfortunately, the growth of our technologies has exceeded our supply of qualified talent. 90 percent of the world's data today has been generated in the last two years, and we can't keep up with demand. According to a recent McKinsey & Company big data report, by 2018, the United States alone could face a shortage of 140,000 to 190,000 professionals with deep analytical skills, as well as 1.5 million managers and analysts with the know-how to use the analysis of big data to make effective decisions.

To keep up with the demand and fill the talent void, colleges and universities are developing innovative master's degrees in business analytics that are ideal for recent undergraduates with a quantitative background (i.e. science, technology, engineering, math and business degrees). Having a master's degree has been shown to improve students' chances of securing a job, with the benefits higher for those who secure a master's degree over a bachelor's degree alone.

Recently, higher-education consulting firm Eduvantis reported that in the past three years there have been more than 15 new master's-level degree programs centered on data analytics launched in North America. This type of degree is a focused, business-meets-analytics program that can be completed in one year or less (called a Master of Science in Business Analytics or MS-BA). At this time, only a handful of universities offer an MS-BA degree.

Many of the programs offer a focus on experiential learning, and students work on actual companies' business problems to gain real-world experience. Further, the curriculum is often designed around skills companies specifically need in this area. Students in these programs typically require zero to two years of work experience.

For those who are more seasoned working professionals, some MBA programs offer specializations in information systems management, which can help with business analytics. Often, part-time MBA programs are available, so students can continue to work. In fact, some large corporations even pay for top employees to participate in these programs.

No matter which path students or professionals decide to take, obtaining a master's degree in the high-growth field of information systems or specifically business analytics has big benefits. For the individual, a master's degree in this field offers better credentials when pursuing higher-level roles in a company and more experience relevant to this exciting time of technological growth. These graduates are also helping fill the talent gap created by the changing demands of big data.

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Source: http://www.huffingtonpost.com/amy-hillman/the-rise-in-businessanaly_b_3273749.html

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Tuesday, May 14, 2013

Deal of the Day: 26% off the Seidio OBEX Waterproof Case for iPhone 5

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Kings Of Leon Debut 'Always The Same' Ahead Of Hangout Fest

Kings give fans first taste of their upcoming album, will headline this weekend's festival in Alabama.
By James Montgomery

Source: http://www.mtv.com/news/articles/1707205/kings-of-leon-always--the-same-new-single.jhtml

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Samsung To Launch 5G By 2020, Hits Speeds Of 1Gbps In Tests

samsung-logoSamsung Electronics has developed core technology that will allow it to deliver high-speed 5G wireless data connections to consumers by 2020, the company announced today. The system allows data transmission up to several hundred times faster than current 4G networks.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/N6W9UoAuOZQ/

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Minnesota Votes to Allow Gay Marriage (ABC News)

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Activist investor to push for new debt deal at PagesJaunes

By Christian Plumb and Matthieu Protard

PARIS (Reuters) - Activist investor Guy Wyser-Pratte said he is seeking board seats at French phone directories company PagesJaunes to force its biggest shareholder - U.S. private equity firm Cerberus - to cut the group's debt.

PagesJaunes has been struggling with big debts since a private equity buyout of the company in 2006. The firm has also had to cope with the impact of the Internet on its printed directories businesses.

Wyser-Pratte, a U.S. investor who focuses on European companies, has built up a 0.85 percent stake in PagesJaunes, which he said was enough to mount a challenge to Cerberus .

Cerberus became PagesJaunes' biggest shareholder, with 28 percent of voting rights, via the purchase of debt from Mediannuaire, a holding company controlled by Goldman Sachs Group and private equity firm KKR & Co .

A restructuring earlier this year has cut the debt but Wyser-Pratte said this had not done enough for PagesJaunes.

"These people have left them hocked up to the eyeballs, and it's not right," told Reuters on Monday. "That's the first goal, get this thing renegotiated, and with two people on the board ... I think we've got a good shot at it."

He plans to seek investor support to vote himself and Pierre Nollett as independent directors at PagesJaunes' June 5 shareholder meeting.

Wyser-Pratte said his 0.85 percent stake was enough to propose resolutions for the annual meeting.

"We're on the side of management," he said. "They feel like they've gotten short shrift. They're in shackles with this debt."

Cerberus was not immediately available for comment.

PagesJaunes' net debt was more than four times its earnings before interest, tax, depreciation and amortization in 2012, compared with an industry average of 0.78 times, according to Thomson Reuters data.

PagesJaunes said it had received a letter from Wyser-Pratte demanding the appointment of two board members. The company declined further comment.

Shares in PagesJaunes, which is renaming itself Solocal Group, rose 4.2 percent.

"Guy Wyser-Pratte's activist stance is fuelling speculation on the stock," Gilbert Dupont analyst Jean-Baptiste Sergeant said. "If he manages to unite the minority shareholders, he'll seek a sale to a big group and work out the problem of the remaining debt."

(Editing by Jane Merriman)

Source: http://news.yahoo.com/activist-investor-push-debt-deal-pagesjaunes-173523735.html

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Sunday, May 12, 2013

Obama calls on Congress to help more homeowners

WASHINGTON (AP) ? President Barack Obama says Congress must give more homeowners the chance to refinance their mortgages to save money.

Obama says more than 2 million people are saving about $3,000 a year after restructuring their loans under his administration but that more deserve the same chance.

In his weekly radio and Internet address, Obama also calls on the Senate to confirm "without delay" his choice of Democratic Rep. Mel Watt to lead the Federal Housing Finance Agency, which oversees government-controlled mortgage lenders Fannie Mae and Freddie Mac.

Obama says the North Carolina congressman helped enact rules to protect consumers from dishonest lenders.

In the Republican address, Alabama Rep. Martha Roby discusses legislation passed by the GOP-controlled House to give private-sector workers the right to trade overtime pay for additional time off.

___

Online:

Obama's address: www.whitehouse.gov

Republican address: www.youtube.com/HouseConference

Source: http://news.yahoo.com/obama-calls-congress-help-more-homeowners-100546905.html

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Kristen Wiig returns to 'SNL' with Target Lady

TV

9 hours ago

Image: Kristen Wiig

NBC

Kristen Wiig brought Target Lady back to "Saturday Night Live."

Former "Saturday Night Live" castmember Kristen Wiig returned to host the show just a year shy of Mick Jagger giving her an emotional sendoff in last season's finale.

In her ridiculously charming opening monologue, Wiig sang to the tune of The Pointer Sisters? ?I?m So Excited? to show how good she felt about being back on "SNL." She explored backstage to prove how well she knew the show's inner workings, but at every turn she got the details totally wrong.

Wiig misidentified Jason Sudeikis and others, tasered Kenan Thompson, and thought the janitor?s closet was her old dressing room. (Maya Rudolph and Jonah Hill were inside the closet making out.)

PHOTOS: From Live TV to the Big Screen: 12 'SNL' Sketches Made Into Movies

But despite Wiig?s charisma, many of the sketches left little impression ? good or bad. Among the better of the show?s moments came when Wiig starred in a hilarious 1-800 Flowers ad celebrating mothers. Her mom (played by Kate McKinnon) was pretty terrible, asking if Wiig should keep the flowers because her ?apartment is so sad"; demanding to know if there were any nuts in her eggs benedict at a restaurant; and asking for updates about years-old celebrity scandals.

She reprised her role as Target Lady, the cashier from hell who comments on her customer?s every purchase.

?Degree deodorant,? she said in surprise disgust, looking at Aidy Bryant?s item. She asked Vanessa Bayer what she was buying Maxi Pads were for.

Wiig and Cecily Strongteamed up for a totally weird sketch that somehow worked. The women played two 30-somethings working in finance who were double dating with a pair of sixth graders (Bobby Moynihan and Tim Robinson). The women wreaked of ditzy desperation, remarking on how old they felt because the boys didn?t know who Steve Urkel was, and fawning over one of the young lad?s knowledge of dinosaurs.

VIDEO: 'SNL' Recap: Zach Galifianakis Plays 'Game of Game of Thrones'

Perennially unprepared music duo Garth and Kat (Fred Armisen and Wiig) reunited on "Weekend Update" to Seth Meyer?s annoyance. As always, the pair had not practiced, with Meyers noting the pair had a year to prepare yet hadn?t done so, and calling their effort ?terrible.?

In its cold open, "SNL"improbably combined the Cleveland kidnapping case, the Jodi Arias murder trial, and the U.S. Senate hearing on Benghazi. Republican Sen. Darrell Issa (Bill Hader) called on Arias (Nasim Pedrad) to testify. Democratic Sen. Elijah Cummings (Kenan Thompson) accused his colleague of bringing Arias onstage in order to increase TV ratings and draw more attention to the hearing.

?What?s next? The guy from Cleveland who kept those women in his basement?" asked an exasperated Cummings. As it turned out, accused Cleveland kidnapper Ariel Castro (Monihan) was on hand to demand when it would be his turn to testify.

"SNL" concludes season 38 next week with host Ben Affleck and musical guest Kanye West.

How did Wiig do? Which was your favorite skit? Tell us in the comments!

Source: http://www.today.com/entertainment/kristen-wiig-returns-saturday-night-live-target-lady-1C9888228

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Switched On: Three days without Google Glass

Each week Ross Rubin contributes Switched On, a column about consumer technology.

DNP Switched On Three days without Google Glass

The television. The PC. The cellphone. We take the things in these sentence fragments for granted today, but they took many years to enter the mainstream. Could Google Glass herald the next great product that we will one day wonder how we lived without? Based on three days of not using the product, you may want to ask someone else.

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Source: http://www.engadget.com/2013/05/12/three-days-without-google-glass/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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DNA test shows Ohio kidnap suspect fathered girl

Culema Nevarez adds balloons to a growing tribute outside the hole of Gina DeJesus in Cleveland Friday, May 10, 2013. DeJesus was freed Monday from the home of Ariel Castro where she and two other women had been held captive for nearly a decade. (AP Photo/Mark Duncan)

Culema Nevarez adds balloons to a growing tribute outside the hole of Gina DeJesus in Cleveland Friday, May 10, 2013. DeJesus was freed Monday from the home of Ariel Castro where she and two other women had been held captive for nearly a decade. (AP Photo/Mark Duncan)

Balloons surround the porch at the home of Gina DeJesus in Cleveland Friday, May 10, 2013. DeJesus was freed Monday from the home of Ariel Castro where she and two other women had been held captive for nearly a decade. (AP Photo/Mark Duncan)

Deborah Knight, grandmother of Michelle Knight, drives her wheelchair past the home of Gina DeJesus in Cleveland Friday, May 10, 2013. Michelle Knight was freed from the home of Ariel Castro along with DeJesus and Amanda Berry Monday where the 52-year-old man had held them captive for a decade. (AP Photo/Mark Duncan)

A member of the Guardian Angels stands watch outside the home of Gina DeJesus in Cleveland Friday, May 10, 2013. DeJesus was freed Monday from the home of Ariel Castro where she and two other women had been held captive for nearly a decade. (AP Photo/Mark Duncan)

Deborah Knight, center, grandmother of Michelle Knight, drives her wheelchair past the home of Gina DeJesus in Cleveland Friday, May 10, 2013. Michelle Knight was freed from the home of Ariel Castro along with DeJesus and Amanda Berry Monday where the 52-year-old man had held them captive for a decade. (AP Photo/Mark Duncan)

(AP) ? As relatives of the Cleveland kidnapping and rape suspect recounted claims of his unnerving paranoia and violent outbursts, DNA testing confirmed the man who allegedly held three women captive for nearly a decade is the father of a 6-year-old girl who escaped from the house along with the women.

Ariel Castro, charged with rape and kidnapping, remained jailed Friday under a suicide watch on $8 million bond while prosecutors weighed more charges, including some that might carry the death penalty. Public defender Kathleen Demetz, who said she is acting as Castro's adviser while he awaits a full-time attorney, said Friday she can't speak to his guilt or innocence and said only that she advised him not to talk to reporters.

But those who know the 52-year-old Castro are speaking up, saying he was often angry, paranoid and prone to violent outbursts against the mother of his children. He frequently beat her, played bizarre psychological games and locked her indoors, they said.

The stories, repeated in separate interviews with The Associated Press by members of Castro's extended family, have surprised people who knew him as a musician who played bass in several bands around Cleveland the last two decades.

Miguel Quinones, manager of a group Castro played with twice as a backup bass player about five years ago, said he had nothing bad to say about Castro based on his own experiences.

But in the interviews, some of Castro's ex-relatives said he frequently flashed his compulsions for secrecy and terrifying rage that often led him to beat his common-law wife, Grimilda Figueroa.

Figueroa left Castro years ago and died in 2012 after a long illness. Their early years together were happy, but something inside Castro snapped after the birth of their first child, they said.

Castro pushed her down the stairs, fractured her ribs, broke her nose several times, cracked a tooth and dislocated both shoulders, they said. In one incident, he shoved Figueroa into a cardboard box and closed the flaps over her head, they said. He kept her and children imprisoned, cut off from friends and family, and Figueroa couldn't even unlock her own front door, they said.

Figueroa filed domestic-violence complaints, accusing Castro of threatening many times to kill her and her daughters. She charged that he frequently abducted the children and kept them from her, even though she had full custody, with no visitation rights for Castro.

"When I go over there to visit her, and I ask her, 'Nilda, I'm here, open the door,' she's like, 'I can't. Ariel has the key,'" Figueroa's sister, Elida Caraballo, recalled.

Two of the women freed from Castro's home, including the one who gave birth to the girl, returned to relatives' houses earlier this week. The third woman, Michelle Knight, was released from a hospital Friday with a request that her privacy be respected.

"Michelle Knight is in good spirits and would like the community to know that she is extremely grateful for the outpouring of flowers and gifts," the statement said.

A police report alleged that Castro impregnated one of his captives at least five times and made her miscarry by starving her and punching her in the stomach. The report also said another one of the women, Amanda Berry, was forced to give birth in a plastic kiddie pool.

Tests by the state attorney general's office on a sample of Castro's DNA confirmed he fathered Berry's 6-year-old daughter, who was rescued from his house, the office said Friday. After her release, the girl returned home with the 27-year-old Berry. Officials also were entering the DNA profile into a national database to see if it links him to other crimes.

The three women said Castro chained them up in the basement but eventually let them live on the home's second floor. Each woman told a similar story about being abducted after accepting a ride from him.

The FBI has not recovered human remains in its search of the house, spokeswoman Vicki Anderson said Friday. Agents removed more than 200 pieces of evidence, she added, declining to say what was found.

Berry and former captive Gina DeJesus, 22, went home with relatives Wednesday.

The AP does not usually name people alleging sexual assault without their consent, but the names of the three women were widely circulated by their families, the media and law enforcement for years.

___

Associated Press writers Meghan Barr, Mike Householder, Thomas J. Sheeran and Andrew Welsh-Huggins and AP freelance writer John Coyne in Cleveland; Brendan Farrington in Florida; and Dan Sewell in Cincinnati contributed to this report along with news researcher Rhonda Shafner in New York.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-05-11-Missing%20Women%20Found/id-aa031eeccef748c4b2086ce353b2b4df

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PayPal's chief information security officer says passwords' days are numbered

DNP PayPal's chief information security officer says passwords' days are numbered

Recently speaking at the Interop IT conference, PayPal's chief information security officer, Michael Barrett, stated that passwords and PINs were operating on borrowed time. Barrett hopes to replace online security keys with a setup that's a blend of software and hardware-based identification. He also serves as president of the Fast Identity Online Alliance (FIDO) -- the organization's focus is to combine an effective mix of software (passwords and plugins) and hardware (USB drives and fingerprint scanners) for user authentication.

PayPal's technology boss didn't allude to his company adopting these new types of security systems for its customers anytime soon. Instead he announced that FIDO-enabled devices will be hitting the market sometime this year. Progress, yes, but until this hardware becomes more widely available, it's likely that you'll be spending more time getting acquainted with two-step logins.

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Source: Macworld

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Saturday, April 20, 2013

Same protein that fires up cancer-promoting erk also blocks its activation

Apr. 19, 2013 ? A protein which is intimately involved in cancer-promoting cell signaling also keeps a key component of the signaling pathway tied down and inactive, a team led by scientists from The University of Texas MD Anderson Cancer Center reports this week in Nature Structural Molecular Biology.

Shc, pronounced "schick," plays a key role in activating signals which lead to cell proliferation (and cancer) when cells are stimulated, however it unexpectedly turns out to be a tumor-suppressor, keeping Erk under wraps when a cell is less active, said senior author John Ladbury, Ph.D., professor in MD Anderson's Department of Biochemistry and Molecular Biology.

"Shc is a checkpoint to prevent out of control cell growth, binding to Erk when a cell is not being stimulated by growth factors," Ladbury said. "Otherwise, the lower-level background signaling that's always present in a cell would be uncontrolled."

Keeping Erk in check while the cell idles

Overexpression of Erk occurs in many types of cancer, including ovarian and prostate cancer and Hodgkin lymphoma, so cellular control of its activity is important.

In the absence of external stimulation by growth factors, cells remain active but lower levels of cell signaling occur, which Ladbury compares to a car idling, ready to roll. Under these conditions control mechanisms are in place to prevent the cell kicking into gear. Shc turns out to be one of these controllers.

"We're essentially looking at the cell in a resting, but ready, state," Ladbury said. "I would argue that's probably more like a cell behaves in tissue, it's not normally getting a slug of growth factors as is often the way when we investigate signaling in experiments in the lab. There's still a lot going on in the cell, basically background activity." These findings point to a number of therapeutic possibilities, including the measurement of Shc concentration levels as a diagnostic tool and of finding small molecule drugs that block growth-factor signaling to Shc, keeping it bound to Erk, Ladbury noted.

Growth factors provide double boost for Erk

When the appropriate growth factor receptor is stimulated Erk is activated in the MAP Kinase pathway. It dives into the cell nucleus and turns on a variety of genes, actions that contribute to cancer proliferation, blood vessel production and metastasis when signaling is out of control.

When receptor tyrosine kinases on the cell surface connect with growth factors, they normally send a signal via Shc that sets off a chain of actions leading to Erk activation. Ladbury and colleagues looked at Shc's connections to epidermal growth factor receptor (EGFR) signaling.

The team found in mammalian cell lines that:

  • Under non-stimulated conditions Shc binds to Erk in the cell cytoplasm at binding sites that are unique on both proteins.
  • Stimulation via EGFR reduces this connection, but not by competing with Shc at the Shc-Erk binding site.
  • Instead, on stimulation from outside the cells, EGFR adds phosphate groups to itself at specific sites. One of these forms a binding for Shc, which distorts the protein's shape, making it impossible for Erk to bind.
  • Overexpression of Shc decreases the amount of activated Erk, because Shc mops up free Erk molecules.
  • Depleting Shc expression with short hairpin RNA resulted in higher levels of activated Erk.
  • When separated from Shc, Erk moves into the nucleus and activates genes even when the cell is not receiving a stimulus. Thus without the controlling influence of Shc, Erk can run riot in the cell giving rise to unrestrained cell reproduction.

Shc-Erk connection confirmed

Ladbury and colleagues then tested their results in the C.Elegans, a worm model frequently employed in biological research. Both Shc and Erk are greatly similar between humans and the worms.

Experiments showed that Shc blocks Erk function by sequestering it away from the Ras-Raf-Mek MAPK pathway in the worms. Without the Shc-Erk connection, the MAPK pathway is activated, causing excessive Erk activation.

EGFR stimulation not only sets off the normal activation of Erk via Shc and the MAPK pathway, Ladbury said, but also frees Erk for greater availability for activation by breaking the tie to Shc.

Co-authors with Ladbury are first author Kin Man Suen and Chi-Chuan Lin, Ph.D., Fernando Melo, Ph.D., Zamal Ahmed, Ph.D., and Stefan Arold, Ph.D., all of MD Anderson's Department of Biochemistry and Molecular Biology; Roger George, Ph.D., of the London Research Institute of Cancer Research UK; Eleanor Biggs, of the University of Bath, Bath, UK; and Melanie Drake and Swathi Arur, Ph.D., of MD Anderson's Department of Genetics.

Suen is a graduate student in The University of Texas Graduate School of Biomedical Sciences, which is run jointly by MD Anderson and The University of Texas Health Science Center at Houston. Ladbury and Arold also are affiliated with the Center for Biomolecular Structure and Function at MD Anderson.

Funding for this research was provided by grants from the U.S. National Institutes of Health (GM98200), the G. Harold and Leila Y. Mathers Charitable Foundation and the MD Anderson Cancer Center Trust. MD Anderson also receives a Cancer Center Support Grant from the National Cancer Institute of the National Institutes of Health (P30 CA016672).

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The above story is reprinted from materials provided by University of Texas M. D. Anderson Cancer Center.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Kin Man Suen, Chi-Chuan Lin, Roger George, Fernando A Melo, Eleanor R Biggs, Zamal Ahmed, Melanie N Drake, Swathi Arur, Stefan T Arold, John E Ladbury. Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli. Nature Structural & Molecular Biology, 2013; DOI: 10.1038/nsmb.2557

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/ZYwNcwUze0A/130419171603.htm

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Thursday, April 18, 2013

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Source: http://forums.ferra.ru/index.php?showtopic=55502

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Wednesday, April 17, 2013

Laser liposuction melts fat, results in tighter skin

Apr. 15, 2013 ? A new, minimally invasive treatment that uses lasers to melt fat could replace the "tummy tuck," suggests research on more than 2,000 people being presented at the Society of Interventional Radiology's 38th Annual Scientific Meeting in New Orleans.

Without the risks of a surgical procedure (such as the tummy tuck) and when used in combination with standard liposuction, the fat-melting action of laser lipolysis, a minimally invasive treatment, has the added benefit of producing new collagen (collagen is the main protein that gives the skin its tone and texture). Additionally, the laser causes the collagen to contract, which tightens the skin. This tightening alleviates the fear of skin sagging, a common complaint after standard liposuction. Laser lipolysis also enables the removal of more fat than standard liposuction.

"Many women who have standard liposuction are discouraged because often the skin sags after the fat is removed," said Abbas Chamsuddin, M.D., lead author of the study and an interventional radiologist at the Center for Laser and Interventional Surgery in Atlanta, Ga. "Ultrasound-assisted guidance of a fiber-optic laser during laser lipolysis can be used on many parts of the body and results in excellent sculpting with tight skin," he added.

"Liposuction has been around for more than 20 years. Many people don't try it because they have heard that the skin often sags after the fat is removed. This is especially true for individuals who want to lose abdominal fat, but also need the skin to retract. Traditional liposuction also has a limitation to the volume of fat that could potentially be removed," said Chamsuddin. "Combining traditional liposuction with laser lipolysis has now been shown to produce well-sculpted bodies with tight skin. We are able to give people things such as a tighter abdomen without the need for surgery," he said.

Between February 2009 and July 2012, a group of 2,183 individuals, ages 17 to 73 (75 percent female, 25 percent male), underwent laser-assisted lipolysis and liposuction on multiple areas of the body, including the neck, arms, love handles, breast, belly, thighs and calves. Prior to treatment, each person had measurements recorded including weight, diameter of the area treated and skin tightness. At each follow-up appointment the diameter of the treatment areas was measured and recorded. Skin tightness was also recorded against control criteria.

The laser's thermal (heat) energy melts the fat and standard liposuction removes it from the body, noted Chamsuddin. Patient follow-up was daily for a week and then at one, three and six months. All treated areas showed improvement in reducing fat bulk as well as tightening skin. The laser uses targeted energy to "zero in" on the fat, without affecting the other tissue, enabling a faster recovery, he added.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/mj1MBKviE1I/130415124819.htm

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Tuesday, April 16, 2013

Google's MyGlass Companion App for Google Glass Is Now Available in Google Play

Though this is completely useless for pretty much every single one of us (since we don't have Google Glass), Google just released the companion Android app for Google Glass called MyGlass in Google Play. Even Google so cheekily reminds us that the app does nothing (without Glass, that is) saying: "If you don't have Glass, then downloading this will be a waste of time. Sorry about that. But if you swipe the screenshots to the right you'll see there's a picture of a puppy in pajamas. So not a total waste of time after all." More »
    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/IcRoLnq9rVc/googles-myglass-companion-app-for-google-glass-is-now-available-in-google-play

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Google Glass Has 12GB Of Usable Storage And A 5MP Camera, Official Specs Reveal

google glassGoogle Glass is arriving soon, with lucky Explorer program members getting their devices soonish, with units rolling off the production line right now, but you can find out right now what kind of hardware specs the gadget has thanks to a Google Glass support doc. The display is said to be equivalent to viewing a 25-inch HD display from eight feet, the camera captures 5 megapixel stills and 720p video, there's 16GB of flash memory, of which 12GB are usable, and it has both Wi-Fi and Bluetooth on board.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/7Y5GVkwgMfw/

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High court rejects challenge to NY gun law

(AP) ? The Supreme Court is staying out of the gun debate for now.

The justices on Monday declined to hear a challenge to a strict New York law that makes it difficult for residents to get a license to carry a concealed handgun in public.

The court did not comment in turning away an appeal from five state residents and the Second Amendment Foundation. Their lawsuit also drew support from the National Rifle Association and 20 states.

The high court action comes amid an intensifying congressional debate on new gun control measures. The issue has resurfaced prominently in Washington in the wake of the Newtown, Conn., school shooting that killed 20 children and six adults.

Associated Press

Source: http://hosted2.ap.org/apdefault/89ae8247abe8493fae24405546e9a1aa/Article_2013-04-15-US-Supreme-Court-Guns/id-1046c69611994cf2983ee5a718e781f8

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Monday, April 15, 2013

The Note's Must-Reads for Monday, April 15, 2013

The Note's Must-Reads are a round-up of today's political headlines and stories from ABC News and the top U.S. newspapers. Posted Monday through Friday right here at www.abcnews.com

Compiled by ABC News' Jayce Henderson and Carrie Halperin

NORTH KOREA: The Washington Times' Guy Taylor: " N. Korea talks hinge on ending nuke plan" After meeting with Japanese leaders Sunday, Secretary of State John F. Kerry signaled that the U.S. is prepared to engage in talks with North Korea if it moves toward abandoning its nuclear program. During an intimate question-and-answer session Sunday night with reporters traveling through Asia with him, Mr. Kerry said the United States is "prepared to reach out" to 29-year-old North Korean leader Kim Jong-un, but doing so would require the "appropriate moment" and "appropriate circumstances." LINK

The Wall Street Journal's Jay Solomon: " U.S. Offers Direct Korea Talks" Secretary of State John Kerry said he would be willing to open a direct U.S. diplomatic channel to North Korea's leadership in a bid to reduce tensions in Northeast Asia, if Pyongyang signaled it would move to begin dismantling its nuclear-weapons arsenal. The U.S. proposal marked a considerable softening by the Obama administration of its rhetoric toward North Korea after a massive display of U.S. military force on the Korean peninsula-including the deployment of B-2 bombers, F-22 stealth fighters and advanced missile-defense systems. LINK

GUN CONTROL: The New York Daily News' Adam Edelman: " Bipartisan gun control compromise headed for Senate debate - 'It's going to be close,' says pol" One of the two senators behind a breakthrough compromise on gun-control legislation questioned Sunday whether the watered-down deal could muster enough votes to get through a divided senate, even as a flock of GOP lawmakers moved toward the bill. "It's an open question on whether or not we have the votes," Pennsylvania Republican Sen. Pat Toomey said Sunday of the deal he and West Virginia Democrat Sen. Joe Manchin reached last week on gun-sales background checks. LINK

USA Today's Richard Wolf: " High court may decide on carrying guns outside home" Guns are on the docket in Congress and dozens of state legislatures. Can the Supreme Court be far behind? The court may decide as early as Monday to consider whether the Second Amendment's right to keep a gun for self-defense extends outside the home. The case under consideration is a challenge to New York's law that requires "proper cause" to carry a weapon in public. Ten states, including California, New Jersey, Massachusetts and Maryland, have similar restrictions. Most have been challenged in court. LINK

COUNTER-TERRORISM: The Los Angeles Times' Ken Dilanian: " With Al Qaeda shattered, U.S. counter-terrorism's future unclear" Skilled in tracking foreign terrorists, Jarret Brachman once was a sought-after expert on Al Qaeda, advising several federal agencies and speaking regularly around the country. Now the former research director of the Combating Terrorism Center, a think tank at the U.S. Military Academy at West Point, has turned his focus away from Islamic militants. He spends most of his time consulting with federal, state and local law enforcement agencies about threats from domestic extremists and anti-government militias. LINK

CONGRESS: The Washington Post's David Nakamura: " With endorsement of immigration plan, Rubio makes first major policy gambit of his career" It was early one morning in December when Richard J. Durbin spotted Marco Rubio in the members-only Senate gym. Dedicated fitness buffs, the two had become unlikely workout buddies. Now Durbin (D-Ill.) wanted to know whether Rubio (R-Fla.) would join him in another heavy lift: a fledgling bipartisan group tackling immigration reform. LINK

Politico's John Bresnahan and Jake Sherman: " Mitch McConnell in no mood for bipartisanship" Mitch McConnell still hasn't gotten over December's traumatic fiscal cliff showdown. The Senate minority leader has signaled privately that he has no interest in sitting in the same room as Majority Leader Harry Reid (D-Nev.) to discuss a possible "grand bargain" on budget and tax issues, Senate insiders tell POLITICO. LINK

ECONOMY: Bloomberg's Jonathan Burgos: " Asian Stocks Drop as China GDP Grows Less Than Estimated" Asian stocks dropped, with the regional benchmark index retreating from the highest level in 20 months, after Chinese economic growth and industrial production expanded less than economists' estimated. Jiangxi Copper Co., China's largest copper producer, plunged 5 percent in Hong Kong. Newcrest Mining Ltd., Australia's biggest gold producer, sank 8.7 percent, after the bullion tumbled to the lowest price in almost two years. LINK

OTHER: The Hill's Sam Baker: " Supreme Court Wrestles with right to patent human genes" Do companies have the right to patent your genes? The Supreme Court will wrestle with that highly charged question on Monday, when it hears oral arguments in a case that could have far-reaching implications for the future of medical research. The federal government itself is divided over the issue. The federal patent office has been approving patents on human genes since the 1980s, but the Justice Department on Monday will ask the court to invalidate those protections and rule that human genes cannot be patented. LINK

The New York Times' William Neuman: " Venezuela Gives Ch?vez Prot?g? Narrow Victory" In an unexpectedly close race, Venezuelans narrowly voted to continue Hugo Ch?vez's revolution, electing his handpicked political heir, Nicol?s Maduro, to serve the remainder of his six-year term as president, officials said late Sunday. LINK

ABC VIDEO: " North Korea Missile Threat Escalates" LINK

BOOKMARKS: The Note: LINK The Must-Reads Online: LINK Top Line Webcast (12noon EST M-F): LINK ABC News Politics: LINK George's Bottom Line (George Stephanopoulos): LINK Follow ABC News on Twitter: LINK ABC News Mobile: LINK ABC News app on your iPhone/iPod Touch/iPad: LINK

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Source: http://news.yahoo.com/notes-must-reads-monday-april-15-2013-082831988--abc-news-politics.html

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Activists say Syrian airstrike kills 12 civilians

BEIRUT (AP) ? A Syrian government airstrike on a town in the country's northwest killed at least 12 people Saturday, shattering store fronts, setting cars ablaze and sending a giant plume of black and gray smoke over the horizon.

President Bashar Assad's air force has been one of his biggest assets in the 2-year-old civil war and he has used warplanes and helicopters to try to check rebel advances, although the regime also frequently hits civilian areas.

A Human Rights Watch report this week accused the Syrian government of committing war crimes by using indiscriminate and sometimes deliberate airstrikes against civilians, killing at least 4,300 people since the summer.

Saturday's air raid struck the town of Saraqeb in Idlib province, according to the Britain-based Syrian Observatory for Human Rights activist group. The Observatory said four of the 12 people killed in the attack were members of the same family. Many others were wounded and the death toll was expected to rise, the Observatory said.

Amateur videos posted online showed a giant plume of black smoke, and people in cars and on motorbikes rushing to help the wounded. A group of men can be seen carrying a wounded man covered in gray dust. Another man in the video rushes with a bucket of water to help extinguish cars in flames. Rubble and twisted metal littered the street.

The video appeared genuine and corresponded to other reporting by The Associated Press of the events depicted.

Rebels have wrested much of the countryside of Idlib and other provinces in northern Syria from regime forces, although government troops still control many military bases in the region from which they launch attacks ? including airstrikes ? on opposition-held areas.

South of Saraqeb, Syrian government troops trying to relieve a besieged military base ambushed a rebel checkpoint, killing at least 12 opposition fighters.

The Observatory said the government forces surprised the rebel fighters on the outskirts of the village of Baboulein. The Observatory, which relies on a network of local activists on the ground, said many opposition fighters were also wounded in the attack.

Observatory director Rami Abdul-Rahman said the assault was part of government efforts to resupply the embattled military base at Wadi Deif outside of the town of Maaret al-Numan, which is just north of Baboulein on the Damascus-Aleppo highway.

Rebels have been trying for months to capture the large base at Wadi Deif, from which regime troops regularly pound the now largely abandoned town of Maaret al-Numan with artillery fire. The regime must push convoys through rebel-held territory to prevent the base from running short of troops and supplies.

On Thursday, activists said rebels shot down a helicopter carrying food and supplies to the base, killing the pilot and three other soldiers.

In the northern city of Aleppo, a government air raid on the disputed Sheikh Maqsoud neighborhood killed at least three people and wound 16 others, the Observatory said. It added that doctors treating the wounded said many showed symptoms of inhaling toxic gas, such as severe vomiting and irritation to the nose and eyes.

Both sides in the Syrian civil war have accused the other of using chemical weapons.

Syria has asked the U.N. to investigate an alleged chemical weapons attack by rebels in March on the village of Khan al-Assal outside of Aleppo. The rebels blame regime forces.

Britain and France want the U.N. to investigate allegations of chemical weapons use in Khan al-Assal and another village, Ataybah, on March 19, as well as the central city of Homs on Dec. 23.

Syria has rejected U.N. Secretary-General Ban Ki-moon's push to expand the U.N. probe to include those other villages.

The Syrian conflict began in March 2011 with largely peaceful protests but has since devolved into a civil war that the United Nations says has killed at least 70,000 people. Hundreds of thousands of Syrians have sought refuge abroad, and millions inside the country have fled their homes to try to find safety elsewhere inside Syria.

International efforts to find a peaceful resolution to the conflict have faltered.

U.N.-Arab League envoy Lakhdar Brahimi is scheduled to address the U.N. Security Council on Thursday. Brahimi has not been able to make progress in his mission to push forward a peace plan for Syria first presented in June at an international conference in Geneva.

On Saturday, Syrian state-run daily Al-Thawra accused Brahimi of being a "false witness." The daily said he had taken sides in the conflict and that his briefing "will not alleviate the suffering of Syrians."

Brahimi angered the Syrian government in December by saying that the four-decade rule of the Assad family had gone on "too long."

In Rome, the Italian Foreign Ministry said that four Italian journalists who had been detained in Syria since April 4 have been freed. The ministry did not specify who had detained them, or disclose details of their release.

Italian media have reported that the four were a RAI public television reporter and three freelancers who had entered Syria earlier this month with the intention of working by day in Syria and crossing into Turkey in the evening. They were reportedly detained in a rebel-controlled area in northern Syria near the Turkish border.

___

Associated Press writer Bassem Mroue contributed to this report.

Source: http://news.yahoo.com/activists-syrian-airstrike-kills-12-civilians-131225615.html

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